Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid
Unesterified cholesterol accumulation in the late endosomal/lysosomal (LE/LY) compartment is the cellular hallmark of Niemann-Pick C (NPC) disease, caused by defects in Countertop Steamers the genes encoding NPC1 or NPC2.We previously reported the dramatic stimulation of NPC2 cholesterol transport rates to and from model membranes by the LE/LY phos